A Closer Look at the PMPRB Moderate Improvement Designation

One aspect of the revised PMPRB Guidelines implemented in 2010 that was welcomed by the branded pharmaceutical industry was the change to the levels of therapeutic improvement.  Specifically, the old three category system was expanded to four distinct levels:  Breakthrough (BT), Significant Improvement (SI), Moderate Improvement (MI) and Slight or No improvement (SLNO). The creation …

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